• Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism 

      Braadland, Peder; Grytli, Helene Hartvedt; Ramberg, Håkon Andre; Katz, Betina; Kellmann, Ralf; Fazli, Ladan; Krobert, Kurt Allen; Wang, Wanzhong; Levy, Finn Olav; Bjartell, Anders; Berge, Viktor; Rennie, Paul S.; Mellgren, Gunnar; Mælandsmo, Gunhild; Svindland, Aud; Tasken, Kristin Austlid; Gauthier-Landry, Louis; Barbier, Olivier (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      The underlying mechanisms responsible for the development of castration-resistant prostate cancer (CRPC) in patients who have undergone androgen deprivation therapy are not fully understood. This is the first study to address whether β2-adrenergic receptor (ADRB2)- mediated signaling may affect CRPC progression in vivo. By immunohistochemical analyses, we observed that low levels of ADRB2 is associated ...
    • Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer 

      Ramberg, Håkon Andre; Richardsen, Elin; De Souza, Gustavo Antonio; Rakaee, Mehrdad; Stensland, Maria; Braadland, Peder Rustøen; Nygård, Ståle; Ögren, Olov; Guldvik, Ingrid; Berge, Viktor; Svindland, Aud; Tasken, Kristin Austlid; Andersen, Sigve (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-20)
      The demographic shift toward an older population will increase the number of prostate cancer cases. A challenge in the treatment of prostate cancer is to avoid undertreatment of patients at high risk of progression following curative treatment. These men can benefit from early salvage treatment. An explorative cohort consisting of tissue from 16 patients who underwent radical prostatectomy, and were ...